Reactome | trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA

Schema > Reaction > Entries

trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:71049] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667513] RHEA:31201 [DatabaseIdentifier:9977730] RHEA:31201
dbId	77333
displayName	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA
eventOf	[Pathway:R-HSA-77348] Beta oxidation of octanoyl-CoA to hexanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-77332] trans-Oct-2-enoyl-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77407] Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA (2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA
orthologousEvent	[Reaction:R-DRE-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Danio rerio [Reaction:R-DDI-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Caenorhabditis elegans [Reaction:R-DME-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Drosophila melanogaster [Reaction:R-GGA-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Gallus gallus [Reaction:R-XTR-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Xenopus tropicalis [Reaction:R-SSC-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Sus scrofa [Reaction:R-BTA-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Bos taurus [Reaction:R-CFA-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Canis familiaris [Reaction:R-RNO-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Rattus norvegicus [Reaction:R-MMU-77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-77330] (S)-Hydroxyoctanoyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77338] Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2 - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77333
summation	[Summation:179251] ECHS1 in the mitochondrial matrix hydrates trans-oct-2-enoyl...
updateTrackers	[UpdateTracker:9984635] Update Tracker - [Reaction:77333] trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984635] Update Tracker - [Reaction:77333] trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-77348] Beta oxidation of octanoyl-CoA to hexanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H