Reactome | N-atom dealkylation of caffeine

Schema > Reaction > Entries

N-atom dealkylation of caffeine Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76372] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
dbId	76426
displayName	N-atom dealkylation of caffeine
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 - Homo sapiens
input	[SimpleEntity:R-ALL-40727] CAF [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211793] Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	N-atom dealkylation of caffeine
orthologousEvent	[Reaction:R-DRE-76426] N-atom dealkylation of caffeine - Danio rerio [Reaction:R-SSC-76426] N-atom dealkylation of caffeine - Sus scrofa [Reaction:R-BTA-76426] N-atom dealkylation of caffeine - Bos taurus [Reaction:R-RNO-76426] N-atom dealkylation of caffeine - Rattus norvegicus [Reaction:R-MMU-76426] N-atom dealkylation of caffeine - Mus musculus
output	[SimpleEntity:R-ALL-143501] CH2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-76424] Paraxanthine [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-76426
summation	[Summation:178524] Caffeine is one of the world's most frequently consumed xeno...
updateTrackers	[UpdateTracker:9792110] Update Tracker - [Reaction:76426] N-atom dealkylation of caffeine - v24:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792110] Update Tracker - [Reaction:76426] N-atom dealkylation of caffeine - v24:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2