Reactome | Activation, myristolyation of BID and translocation to mitochondria

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Activation, myristolyation of BID and translocation to mitochondria Show undefined attributes

authored	[InstanceEdit:140538] Gopinathrao, G, 2004-08-19 20:25:42
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
crossReference	[DatabaseIdentifier:12819567] BioModels Database:BIOMD0000000525 [DatabaseIdentifier:12819569] BioModels Database:BIOMD0000000523 [DatabaseIdentifier:12819571] BioModels Database:BIOMD0000000524 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819575] BioModels Database:BIOMD0000000526
dbId	75108
displayName	Activation, myristolyation of BID and translocation to mitochondria
doi	10.3180/REACT_701.1
eventOf	[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis - Homo sapiens
figure	[Figure:140543] /figures/tbid1.jpg
goBiologicalProcess	[GO_BiologicalProcess:5673453] positive regulation of protein localization to mitochondrion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-139898] Caspase-8 activates BID by cleavage - Homo sapiens [Reaction:R-HSA-139893] Granzyme-B activates BID by cleavage - Homo sapiens [Reaction:R-HSA-141367] Myristoylation of tBID by NMT1 - Homo sapiens [Reaction:R-HSA-139920] Translocation of tBID to mitochondria - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:141254] Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis [LiteratureReference:140368] The Bcl-2 family: roles in cell survival and oncogenesis.
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activation, myristolyation of BID and translocation to mitochondria Activation of BID and translocation to mitochondria
orthologousEvent	[Pathway:R-GGA-75108] Activation, myristolyation of BID and translocation to mitochondria - Gallus gallus [Pathway:R-XTR-75108] Activation, myristolyation of BID and translocation to mitochondria - Xenopus tropicalis [Pathway:R-DRE-75108] Activation, myristolyation of BID and translocation to mitochondria - Danio rerio [Pathway:R-SSC-75108] Activation, myristolyation of BID and translocation to mitochondria - Sus scrofa [Pathway:R-BTA-75108] Activation, myristolyation of BID and translocation to mitochondria - Bos taurus [Pathway:R-CFA-75108] Activation, myristolyation of BID and translocation to mitochondria - Canis familiaris [Pathway:R-RNO-75108] Activation, myristolyation of BID and translocation to mitochondria - Rattus norvegicus [Pathway:R-MMU-75108] Activation, myristolyation of BID and translocation to mitochondria - Mus musculus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165094] Vaux, D, 0000-00-00 00:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75108
summation	[Summation:140549] BID may promote cell death by activating BAX and BAK while i...
updateTrackers	[UpdateTracker:9789071] Update Tracker - [Pathway:75108] Activation, myristolyation of BID and translocation to mitochondria - v38:[addLiteratureReference] [UpdateTracker:9787790] Update Tracker - [Pathway:75108] Activation, myristolyation of BID and translocation to mitochondria - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789071] Update Tracker - [Pathway:75108] Activation, myristolyation of BID and translocation to mitochondria - v38:[addLiteratureReference] [UpdateTracker:9787790] Update Tracker - [Pathway:75108] Activation, myristolyation of BID and translocation to mitochondria - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis