Reactome | DNA Damage Reversal

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DNA Damage Reversal Show undefined attributes

authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
dbId	73942
displayName	DNA Damage Reversal
doi	10.3180/REACT_127.1
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
eventOf	[TopLevelPathway:R-HSA-73894] DNA Repair - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9346] DNA repair
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-5657655] MGMT-mediated DNA damage reversal - Homo sapiens [Pathway:R-HSA-73943] Reversal of alkylation damage by DNA dioxygenases - Homo sapiens [Pathway:R-HSA-9729902] Reversible DNA damage induced by alkylating chemotherapeutic drugs - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:69939] Regulation of repair of alkylation damage in mammalian genomes. [LiteratureReference:5657611] Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding [LiteratureReference:5657661] The structure of the human AGT protein bound to DNA and its implications for damage detection [LiteratureReference:5658010] Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase [LiteratureReference:5658008] DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy [LiteratureReference:113684] Reversal of DNA alkylation damage by two human dioxygenases. [LiteratureReference:5656417] DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation
maxDepth	4
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	DNA Damage Reversal
orthologousEvent	[Pathway:R-GGA-73942] DNA Damage Reversal - Gallus gallus [Pathway:R-XTR-73942] DNA Damage Reversal - Xenopus tropicalis [Pathway:R-DRE-73942] DNA Damage Reversal - Danio rerio [Pathway:R-SSC-73942] DNA Damage Reversal - Sus scrofa [Pathway:R-BTA-73942] DNA Damage Reversal - Bos taurus [Pathway:R-CFA-73942] DNA Damage Reversal - Canis familiaris [Pathway:R-RNO-73942] DNA Damage Reversal - Rattus norvegicus [Pathway:R-MMU-73942] DNA Damage Reversal - Mus musculus
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
revised	[InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-73942
summation	[Summation:73959] DNA damage can be directly reversed by dealkylation (Mitra a...
updateTrackers	[UpdateTracker:9788618] Update Tracker - [Pathway:73942] DNA Damage Reversal - v41:[updateContainedRLE] [UpdateTracker:9790363] Update Tracker - [Pathway:73942] DNA Damage Reversal - v33:[updateContainedPathway] [UpdateTracker:9775720] Update Tracker - [Pathway:73942] DNA Damage Reversal - v78:[addHasEvent] [UpdateTracker:9791846] Update Tracker - [Pathway:73942] DNA Damage Reversal - v25:[updateContainedPathway] [UpdateTracker:9788840] Update Tracker - [Pathway:73942] DNA Damage Reversal - v40:[updateContainedRLE] [UpdateTracker:9785322] Update Tracker - [Pathway:73942] DNA Damage Reversal - v52:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedPathway] [UpdateTracker:9792016] Update Tracker - [Pathway:73942] DNA Damage Reversal - v24:[updateContainedPathway] [UpdateTracker:9791517] Update Tracker - [Pathway:73942] DNA Damage Reversal - v29:[modifyText] [UpdateTracker:9789099] Update Tracker - [Pathway:73942] DNA Damage Reversal - v38:[updateContainedPathway] [UpdateTracker:9789997] Update Tracker - [Pathway:73942] DNA Damage Reversal - v36:[updateContainedRLE] [UpdateTracker:9783046] Update Tracker - [Pathway:73942] DNA Damage Reversal - v57:[updateContainedPathway] [UpdateTracker:9790246] Update Tracker - [Pathway:73942] DNA Damage Reversal - v34:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788618] Update Tracker - [Pathway:73942] DNA Damage Reversal - v41:[updateContainedRLE]
[UpdateTracker:9790363] Update Tracker - [Pathway:73942] DNA Damage Reversal - v33:[updateContainedPathway]
[UpdateTracker:9775720] Update Tracker - [Pathway:73942] DNA Damage Reversal - v78:[addHasEvent]
[UpdateTracker:9791846] Update Tracker - [Pathway:73942] DNA Damage Reversal - v25:[updateContainedPathway]
[UpdateTracker:9788840] Update Tracker - [Pathway:73942] DNA Damage Reversal - v40:[updateContainedRLE]
[UpdateTracker:9785322] Update Tracker - [Pathway:73942] DNA Damage Reversal - v52:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9792016] Update Tracker - [Pathway:73942] DNA Damage Reversal - v24:[updateContainedPathway]
[UpdateTracker:9791517] Update Tracker - [Pathway:73942] DNA Damage Reversal - v29:[modifyText]
[UpdateTracker:9789099] Update Tracker - [Pathway:73942] DNA Damage Reversal - v38:[updateContainedPathway]
[UpdateTracker:9789997] Update Tracker - [Pathway:73942] DNA Damage Reversal - v36:[updateContainedRLE]
[UpdateTracker:9783046] Update Tracker - [Pathway:73942] DNA Damage Reversal - v57:[updateContainedPathway]
[UpdateTracker:9790246] Update Tracker - [Pathway:73942] DNA Damage Reversal - v34:[updateContainedRLE]

(hasEvent)

[TopLevelPathway:R-HSA-73894] DNA Repair

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