DNA damage can be directly reversed by dealkylation (Mitra and Kaina 1993). Three enzymes play a major role in reparative DNA dealkylation: MGMT, ALKBH2 and ALKBH3. MGMT dealkylates O-6-methylguanine in a suicidal reaction that inactivates the enzyme (Daniels et al. 2000, Rasimas et al. 2004, Duguid et al. 2005, Tubbs et al. 2007), while ALKBH2 and ALKBH3 dealkylate 1-methyladenine, 3-methyladenine, 3-methylcytosine and 1-ethyladenine (Duncan et al. 2002, Dango et al. 2011).
Pegg, AE, Tainer, JA, Tubbs, JL
Daniels, DS, Kanugula, S, Tainer, JA, Mol, CD, Arvai, AS, Pegg, AE
Rasimas, JJ, Pegg, AE, Ropson, IJ, Dalessio, PA, Fried, MG
Rice, PA, He, C, Duguid, EM
Xiong, LJ, Park, K, Mosammaparast, N, Dango, S, Shi, Y, Gygi, S, Sowa, ME, Harper, JW, Wu, F, Rubin, M
Lindahl, T, Duncan, T, Bates, PA, Sedgwick, B, Trewick, SC, Koivisto, P
Mitra, S, Kaina, B
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