Reactome | Internal Methylation of mRNA

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Internal Methylation of mRNA Show undefined attributes

catalystActivity	[CatalystActivity:72094] mRNA m(6)A methyltransferase activity of mRNA (N6-adenosine)-methyltransferase [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643886] mRNA (N6-adenosine)-methyltransferase activity of mRNA (N6-adenosine)-methyltransferase [nucleoplasm] A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:72076] Krainer, AR, 2003-06-05 08:30:23
dbId	72095
displayName	Internal Methylation of mRNA
edited	[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-72203] Processing of Capped Intron-Containing Pre-mRNA - Homo sapiens
input	[Complex:R-HSA-77089] capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72096] Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. [LiteratureReference:6789442] A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation [LiteratureReference:6789452] Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase [LiteratureReference:6789470] Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Internal Methylation of mRNA
orthologousEvent	[Reaction:R-MMU-72095] Internal Methylation of mRNA - Mus musculus [Reaction:R-PFA-72095] Internal Methylation of mRNA - Plasmodium falciparum [Reaction:R-DME-72095] Internal Methylation of mRNA - Drosophila melanogaster [Reaction:R-XTR-72095] Internal Methylation of mRNA - Xenopus tropicalis [Reaction:R-DRE-72095] Internal Methylation of mRNA - Danio rerio [Reaction:R-SSC-72095] Internal Methylation of mRNA - Sus scrofa [Reaction:R-BTA-72095] Internal Methylation of mRNA - Bos taurus [Reaction:R-RNO-72095] Internal Methylation of mRNA - Rattus norvegicus
output	[Complex:R-HSA-71954] capped, methylated pre-mRNA:CBC Complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-77095] Recognition and binding of the mRNA cap by the cap-binding complex - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72095
summation	[Summation:72102] In addition to the methylation of the 5'-cap, there is methy...
updateTrackers	[UpdateTracker:9784479] Update Tracker - [Reaction:72095] Internal Methylation of mRNA - v54:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9784479] Update Tracker - [Reaction:72095] Internal Methylation of mRNA - v54:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-72203] Processing of Capped Intron-Containing Pre-mRNA

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