Reactome | leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]

Schema > Reaction > Entries

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] Show undefined attributes

catalystActivity	[CatalystActivity:70711] branched-chain-amino-acid transaminase activity of BCAT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643240] branched-chain-amino-acid transaminase activity of BCAT2 dimer [mitochondrial matrix] The structure of human mitochondrial branched-chain aminotransferase
category	transition
compartment	[Compartment:5460] mitochondrial matrix
dbId	70724
displayName	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
eventOf	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70713] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [DefinedSet:R-ALL-508190] Leu, Ile, Val [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508232] Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) [LiteratureReference:70705] The structure of human mitochondrial branched-chain aminotransferase. [LiteratureReference:508177] Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
orthologousEvent	[Reaction:R-MMU-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Mus musculus [Reaction:R-SCE-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Saccharomyces cerevisiae [Reaction:R-SPO-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Schizosaccharomyces pombe [Reaction:R-DDI-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Dictyostelium discoideum [Reaction:R-CEL-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Caenorhabditis elegans [Reaction:R-DME-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Drosophila melanogaster [Reaction:R-XTR-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Xenopus tropicalis [Reaction:R-DRE-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Danio rerio [Reaction:R-SSC-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Sus scrofa [Reaction:R-BTA-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Bos taurus [Reaction:R-CFA-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Canis familiaris [Reaction:R-RNO-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Rattus norvegicus
output	[DefinedSet:R-ALL-508181] KIC, KMVA, KIV [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9672770] SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70724
summation	[Summation:178920] Mitochondrial branched-chain-amino-acid aminotransferase (BC...

Referrals

(hasEvent)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-HSA-70713] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
(reverseReaction)	[Reaction:R-HSA-508179] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]

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