Reactome | glutamate + acetyl CoA => N-acetyl glutamate + CoA

Schema > Reaction > Entries

glutamate + acetyl CoA => N-acetyl glutamate + CoA Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70539] L-glutamate N-acetyltransferase activity of NAGS(19-534) dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9644008] L-glutamate N-acetyltransferase activity of NAGS(19-534) dimer [mitochondrial matrix] Cloning and expression of the human N-acetylglutamate synthase gene
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667675] RHEA:24293
dbId	70542
diseaseReaction	[FailedReaction:R-HSA-9955697] NAGS variants don't synthesize N-acetylglutamate - Homo sapiens
displayName	glutamate + acetyl CoA => N-acetyl glutamate + CoA
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] - Homo sapiens
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70529] Cloning and expression of the human N-acetylglutamate synthase gene [LiteratureReference:452029] Mammalian N-acetylglutamate synthase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	glutamate + acetyl CoA => N-acetyl glutamate + CoA
orthologousEvent	[Reaction:R-SCE-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Saccharomyces cerevisiae [Reaction:R-SPO-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Schizosaccharomyces pombe [Reaction:R-DDI-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Dictyostelium discoideum [Reaction:R-XTR-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Xenopus tropicalis [Reaction:R-DRE-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Danio rerio [Reaction:R-SSC-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Sus scrofa [Reaction:R-BTA-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Bos taurus [Reaction:R-CFA-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Canis familiaris [Reaction:R-RNO-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Rattus norvegicus [Reaction:R-MMU-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-30471] NAcGlu [mitochondrial matrix]
regulatedBy	[PositiveRegulation:R-HSA-70543] Positive regulation by 'L-Arg [mitochondrial matrix]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70542
summation	[Summation:178807] Mitochondrial N acetylglutamate synthetase (NAGS) catalyzes ...
updateTrackers	[UpdateTracker:9791150] Update Tracker - [Reaction:70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - v32:[addLiteratureReference, add_removeRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791150] Update Tracker - [Reaction:70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - v32:[addLiteratureReference, add_removeRegulator, modifyText]
(normalReaction)	[FailedReaction:R-HSA-9955697] NAGS variants don't synthesize N-acetylglutamate
(hasEvent)	[Pathway:R-HSA-70635] Urea cycle
(precedingEvent)	[Reaction:R-HSA-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]