Reactome | TPI1 dimer isomerizes DHAP to GA3P

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TPI1 dimer isomerizes DHAP to GA3P Show undefined attributes

catalystActivity	[CatalystActivity:70453] triose-phosphate isomerase activity of TPI1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644044] triose-phosphate isomerase activity of TPI1 dimer [cytosol] Primary structure of human triosephosphate isomerase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667603] RHEA:18587 [DatabaseIdentifier:9933523] RHEA:18587
dbId	70454
deleted	[Deleted:450679] Deletion of instance: 70109
displayName	TPI1 dimer isomerizes DHAP to GA3P
eventOf	[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent	[Reaction:R-HSA-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Homo sapiens [Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P - Homo sapiens [Reaction:R-HSA-163751] D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-75970] DHAP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141467] Primary structure of human triosephosphate isomerase [LiteratureReference:450630] Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TPI1 dimer isomerizes DHAP to GA3P dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
orthologousEvent	[Reaction:R-RNO-70454] TPI1 dimer isomerizes DHAP to GA3P - Rattus norvegicus [Reaction:R-PFA-70454] TPI1 dimer isomerizes DHAP to GA3P - Plasmodium falciparum [Reaction:R-SCE-70454] TPI1 dimer isomerizes DHAP to GA3P - Saccharomyces cerevisiae [Reaction:R-SPO-70454] TPI1 dimer isomerizes DHAP to GA3P - Schizosaccharomyces pombe [Reaction:R-DDI-70454] TPI1 dimer isomerizes DHAP to GA3P - Dictyostelium discoideum [Reaction:R-CEL-70454] TPI1 dimer isomerizes DHAP to GA3P - Caenorhabditis elegans [Reaction:R-DME-70454] TPI1 dimer isomerizes DHAP to GA3P - Drosophila melanogaster [Reaction:R-GGA-70454] TPI1 dimer isomerizes DHAP to GA3P - Gallus gallus [Reaction:R-XTR-70454] TPI1 dimer isomerizes DHAP to GA3P - Xenopus tropicalis [Reaction:R-DRE-70454] TPI1 dimer isomerizes DHAP to GA3P - Danio rerio [Reaction:R-SSC-70454] TPI1 dimer isomerizes DHAP to GA3P - Sus scrofa [Reaction:R-BTA-70454] TPI1 dimer isomerizes DHAP to GA3P - Bos taurus [Reaction:R-CFA-70454] TPI1 dimer isomerizes DHAP to GA3P - Canis familiaris [Reaction:R-MMU-70454] TPI1 dimer isomerizes DHAP to GA3P - Mus musculus
output	[SimpleEntity:R-ALL-29578] GA3P [cytosol]
precedingEvent	[Reaction:R-HSA-71496] Aldolase tetramer cleaves F1,6PP - Homo sapiens [Reaction:R-HSA-70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70481] TPI1 dimer isomerizes GA3P to DHAP
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70454
summation	[Summation:71509] Cytosolic triose phosphate isomerase catalyzes the freely re...
updateTrackers	[UpdateTracker:9791020] Update Tracker - [Reaction:70454] dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792371] Update Tracker - [Reaction:70454] dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9791020] Update Tracker - [Reaction:70454] dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792371] Update Tracker - [Reaction:70454] dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate - v22:[addLiteratureReference]
(replacementInstances)	[Deleted:450679] Deletion of instance: 70109
(precedingEvent)	[Reaction:R-HSA-163751] D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate [Reaction:R-HSA-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate [Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P
(hasEvent)	[Pathway:R-HSA-70171] Glycolysis

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