Reactome | Formation of the Flap Intermediate

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Formation of the Flap Intermediate Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
dbId	69127
displayName	Formation of the Flap Intermediate
eventOf	[Pathway:R-HSA-69183] Processive synthesis on the lagging strand - Homo sapiens
followingEvent	[Pathway:R-HSA-69166] Removal of the Flap Intermediate - Homo sapiens [Reaction:R-HSA-69140] RPA binds to the Flap - Homo sapiens
input	[Complex:R-HSA-68453] Processive complex:Okazaki fragment complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69129] DNA polymerase delta holoenzyme: actionon single-starnded DNA and on double-stranded DNA in the presence of replicative DNA helicases. [LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes. [LiteratureReference:69135] Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating nuclear antigen, and flapendonuclease-1.
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of the Flap Intermediate
orthologousEvent	[Reaction:R-PFA-69127] Formation of the Flap Intermediate - Plasmodium falciparum [Reaction:R-SCE-69127] Formation of the Flap Intermediate - Saccharomyces cerevisiae [Reaction:R-SPO-69127] Formation of the Flap Intermediate - Schizosaccharomyces pombe [Reaction:R-DDI-69127] Formation of the Flap Intermediate - Dictyostelium discoideum [Reaction:R-CEL-69127] Formation of the Flap Intermediate - Caenorhabditis elegans [Reaction:R-DME-69127] Formation of the Flap Intermediate - Drosophila melanogaster [Reaction:R-GGA-69127] Formation of the Flap Intermediate - Gallus gallus [Reaction:R-DRE-69127] Formation of the Flap Intermediate - Danio rerio [Reaction:R-SSC-69127] Formation of the Flap Intermediate - Sus scrofa [Reaction:R-BTA-69127] Formation of the Flap Intermediate - Bos taurus [Reaction:R-CFA-69127] Formation of the Flap Intermediate - Canis familiaris [Reaction:R-RNO-69127] Formation of the Flap Intermediate - Rattus norvegicus [Reaction:R-MMU-69127] Formation of the Flap Intermediate - Mus musculus
output	[Complex:R-HSA-68455] Processive complex:Okazaki fragment:Flap [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69116] Formation of Okazaki fragments - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69127
summation	[Summation:69128] When the polymerase delta:PCNA complex reaches a downstream ...
updateTrackers	[UpdateTracker:9792264] Update Tracker - [Reaction:69127] Formation of the Flap Intermediate - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9792264] Update Tracker - [Reaction:69127] Formation of the Flap Intermediate - v22:[addLiteratureReference]
(precedingEvent)	[Pathway:R-HSA-69166] Removal of the Flap Intermediate [Reaction:R-HSA-69140] RPA binds to the Flap
(hasEvent)	[Pathway:R-HSA-69183] Processive synthesis on the lagging strand

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