Reactome | CDC6 association with the ORC:origin complex

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CDC6 association with the ORC:origin complex Show undefined attributes

authored	[InstanceEdit:176978] Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
dbId	68689
displayName	CDC6 association with the ORC:origin complex
eventOf	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
figure	[Figure:68690] /figures/2.2.4a.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9749215] MCM8 binds CDC6 - Homo sapiens [Reaction:R-HSA-68688] CDC6 association with ORC(1-6) at replication origins - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:68692] ATPase switches controlling DNA replication initiation. [LiteratureReference:68693] Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae [LiteratureReference:68682] Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells [LiteratureReference:68571] Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. [LiteratureReference:68410] Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis [LiteratureReference:68702] Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase [LiteratureReference:68381] Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6 [LiteratureReference:68708] Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization [LiteratureReference:68701] Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis [LiteratureReference:68697] The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast [LiteratureReference:68700] The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CDC6 association with the ORC:origin complex
orthologousEvent	[Pathway:R-PFA-68689] CDC6 association with the ORC:origin complex - Plasmodium falciparum [Pathway:R-SCE-68689] CDC6 association with the ORC:origin complex - Saccharomyces cerevisiae [Pathway:R-SPO-68689] CDC6 association with the ORC:origin complex - Schizosaccharomyces pombe [Pathway:R-DDI-68689] CDC6 association with the ORC:origin complex - Dictyostelium discoideum [Pathway:R-DME-68689] CDC6 association with the ORC:origin complex - Drosophila melanogaster [Pathway:R-GGA-68689] CDC6 association with the ORC:origin complex - Gallus gallus [Pathway:R-XTR-68689] CDC6 association with the ORC:origin complex - Xenopus tropicalis [Pathway:R-DRE-68689] CDC6 association with the ORC:origin complex - Danio rerio [Pathway:R-SSC-68689] CDC6 association with the ORC:origin complex - Sus scrofa [Pathway:R-BTA-68689] CDC6 association with the ORC:origin complex - Bos taurus [Pathway:R-CFA-68689] CDC6 association with the ORC:origin complex - Canis familiaris [Pathway:R-RNO-68689] CDC6 association with the ORC:origin complex - Rattus norvegicus [Pathway:R-MMU-68689] CDC6 association with the ORC:origin complex - Mus musculus
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-68689
summation	[Summation:68691] Cdc6 is a regulator of DNA replication initiation in both ye...
updateTrackers	[UpdateTracker:9775432] Update Tracker - [Pathway:68689] CDC6 association with the ORC:origin complex - v79:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9789509] Update Tracker - [Pathway:68689] CDC6 association with the ORC:origin complex - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9775432] Update Tracker - [Pathway:68689] CDC6 association with the ORC:origin complex - v79:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9789509] Update Tracker - [Pathway:68689] CDC6 association with the ORC:origin complex - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex

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