Reactome | Formation of ORC(1-6) complex

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Formation of ORC(1-6) complex Show undefined attributes

authored	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
dbId	68615
displayName	Formation of ORC(1-6) complex
edited	[InstanceEdit:9750784] Orlic-Milacic, Marija, 2021-08-16
eventOf	[Pathway:R-HSA-68616] Assembly of the ORC complex at the origin of replication - Homo sapiens
followingEvent	[Reaction:R-HSA-113638] Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation - Homo sapiens
input	[Complex:R-HSA-9749104] ORC(1-5):origin of replication [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9734715] p-T195-ORC6 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9734659] Assembly of the human origin recognition complex occurs through independent nuclear localization of its components [LiteratureReference:9735417] Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex [LiteratureReference:9749207] Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Formation of ORC(1-6) complex
orthologousEvent	[Reaction:R-SPO-68615] Formation of ORC(1-6) complex - Schizosaccharomyces pombe [Reaction:R-DDI-68615] Formation of ORC(1-6) complex - Dictyostelium discoideum [Reaction:R-DME-68615] Formation of ORC(1-6) complex - Drosophila melanogaster [Reaction:R-GGA-68615] Formation of ORC(1-6) complex - Gallus gallus [Reaction:R-XTR-68615] Formation of ORC(1-6) complex - Xenopus tropicalis [Reaction:R-DRE-68615] Formation of ORC(1-6) complex - Danio rerio [Reaction:R-SSC-68615] Formation of ORC(1-6) complex - Sus scrofa [Reaction:R-BTA-68615] Formation of ORC(1-6) complex - Bos taurus [Reaction:R-CFA-68615] Formation of ORC(1-6) complex - Canis familiaris [Reaction:R-RNO-68615] Formation of ORC(1-6) complex - Rattus norvegicus [Reaction:R-MMU-68615] Formation of ORC(1-6) complex - Mus musculus
output	[Complex:R-HSA-9749111] ORC(1-6):origin of replication [nucleoplasm]
precedingEvent	[Reaction:R-HSA-68611] Formation of ORC(1-5) complex - Homo sapiens [BlackBoxEvent:R-HSA-9734713] ORC6 translocates to the nucleus - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9750793] Kusic-Tisma, Jelena, 2021-07-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-68615
summation	[Summation:9749115] ORC6 associates with the ORC(1-5) complex to form the ORC(1-...
updateTrackers	[UpdateTracker:9775671] Update Tracker - [Reaction:68615] Formation of ORC(1-6) complex - v78:[add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9775671] Update Tracker - [Reaction:68615] Formation of ORC(1-6) complex - v78:[add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]
(precedingEvent)	[Reaction:R-HSA-113638] Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
(hasEvent)	[Pathway:R-HSA-68616] Assembly of the ORC complex at the origin of replication

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