Reactome | Formation of ORC(1-6) complex

Formation of ORC(1-6) complex

Stable Identifier

R-HSA-68615

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ORC6 associates with the ORC(1-5) complex to form the ORC(1-6) complex (Ghosh et al. 2011). The association of ORC6 with the ORC(1-5) complex is weak and it frequently does not co-immunoprecipitate with the other ORC(1-5) subunits. ORC4 is the only ORC(1-5) subunit that was shown to directly bind to ORC6 (Radichev et al. 2006). Formation of the ORC(2-6) complex was demonstrated in vitro, but its biological significance, if any, is unknown (Ghosh et al. 2011). Some ORC6 mutations reported in Meier-Gorlin syndrome were shown to interfere with ORC6 incorporation into the ORC (Balasov et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
16762929	Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex Radichev, I, Kwon, SW, Zhao, Y, DePamphilis, ML, Vassilev, A	J Biol Chem	2006
21555516	Assembly of the human origin recognition complex occurs through independent nuclear localization of its components Ghosh, S, Vassilev, AP, Zhang, J, Zhao, Y, DePamphilis, ML	J Biol Chem	2011
26139588	Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6 Balasov, M, Akhmetova, K, Chesnokov, I	Am J Med Genet A	2015