ORC6 associates with the ORC(1-5) complex to form the ORC(1-6) complex (Ghosh et al. 2011). The association of ORC6 with the ORC(1-5) complex is weak and it frequently does not co-immunoprecipitate with the other ORC(1-5) subunits. ORC4 is the only ORC(1-5) subunit that was shown to directly bind to ORC6 (Radichev et al. 2006). Formation of the ORC(2-6) complex was demonstrated in vitro, but its biological significance, if any, is unknown (Ghosh et al. 2011). Some ORC6 mutations reported in Meier-Gorlin syndrome were shown to interfere with ORC6 incorporation into the ORC (Balasov et al. 2015).
Radichev, I, Zhao, Y, Vassilev, A, Kwon, SW, DePamphilis, ML
Ghosh, S, Zhao, Y, Vassilev, AP, Zhang, J, DePamphilis, ML
Balasov, M, Akhmetova, K, Chesnokov, I
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