Reactome | PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane

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PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:6809934] phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR2:SBF2 Tetramer [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:6809947] Orlic-Milacic, Marija, 2015-11-13
crossReference	[DatabaseIdentifier:12667424] RHEA:39019
dbId	6809944
displayName	PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
inferredFrom	[Reaction:R-MMU-6809945] PI(3,5)P2 is dephosphorylated to PI5P by the Mtmr2:Sbf2 tetramer at the plasma membrane - Mus musculus
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806224] PI(3,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6809782] Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806240] PI5P [plasma membrane]
precedingEvent	[Reaction:R-HSA-1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane - Homo sapiens [Reaction:R-HSA-6809793] MTMR2 binds SBF2 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809944
summation	[Summation:6809946] Formation of a complex with SBF2 (MTMR13) dramatically incre...

Referrals

(hasEvent)	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane
(inferredTo)	[Reaction:R-MMU-6809945] PI(3,5)P2 is dephosphorylated to PI5P by the Mtmr2:Sbf2 tetramer at the plasma membrane

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