Reactome | TP53 binds STK11 and NUAK1

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TP53 binds STK11 and NUAK1 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6805038] Orlic-Milacic, Marija, 2015-10-16
dbId	6805035
displayName	TP53 binds STK11 and NUAK1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3222004] NUAK1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-164119] STK11 [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6805039] LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation [LiteratureReference:3222010] A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	TP53 binds STK11 and NUAK1
orthologousEvent	[Reaction:R-SSC-6805035] TP53 binds STK11 and NUAK1 - Sus scrofa [Reaction:R-BTA-6805035] TP53 binds STK11 and NUAK1 - Bos taurus [Reaction:R-CFA-6805035] TP53 binds STK11 and NUAK1 - Canis familiaris [Reaction:R-RNO-6805035] TP53 binds STK11 and NUAK1 - Rattus norvegicus [Reaction:R-MMU-6805035] TP53 binds STK11 and NUAK1 - Mus musculus
output	[Complex:R-HSA-6805036] TP53 Tetramer:STK11:NUAK1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6805035
summation	[Summation:6805042] In the presence of STK11 (LTKB1), TP53 associates with NUAK1...

Referrals

(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1

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