Reactome | TP53 binds STK11 and NUAK1

TP53 binds STK11 and NUAK1

Stable Identifier

R-HSA-6805035

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        TP53 binds STK11 and NUAK1 (Homo sapiens)

General

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In the presence of STK11 (LTKB1), TP53 associates with NUAK1 (Zeng and Berger 2006, Hou et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17108107	LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation Zeng, PY, Berger, SL	Cancer Res.	2006
21317932	A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation Hou, X, Liu, JE, Liu, W, Liu, CY, Liu, ZY, Sun, ZY	Oncogene	2011

Participants

Input

Output

TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Regulation of TP53 Activity through Phosphorylation

Orthologous Events

TP53 binds STK11 and NUAK1 (Bos taurus)

TP53 binds STK11 and NUAK1 (Mus musculus)

TP53 binds STK11 and NUAK1 (Rattus norvegicus)

TP53 binds STK11 and NUAK1 (Sus scrofa)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-16)