Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
PRMT5 methylates TP53
Show undefined attributes
Go to Details
authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity
[CatalystActivity:6804376] protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
catalystActivityReference
[CatalystActivityReference:9643246] protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] Arginine methylation regulates the p53 response
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6804380] Orlic-Milacic, Marija, 2015-10-09
dbId
6804383
displayName
PRMT5 methylates TP53
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation - Homo sapiens
input
20 ×
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[Complex:R-HSA-6804371] p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6804374] Arginine methylation regulates the p53 response
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
PRMT5 methylates TP53
orthologousEvent
[Reaction:R-DRE-6804383] PRMT5 methylates TP53 - Danio rerio
[Reaction:R-SSC-6804383] PRMT5 methylates TP53 - Sus scrofa
[Reaction:R-BTA-6804383] PRMT5 methylates TP53 - Bos taurus
[Reaction:R-CFA-6804383] PRMT5 methylates TP53 - Canis familiaris
[Reaction:R-RNO-6804383] PRMT5 methylates TP53 - Rattus norvegicus
[Reaction:R-MMU-6804383] PRMT5 methylates TP53 - Mus musculus
output
20 ×
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[Complex:R-HSA-6804385] p-S15,S20,Me-R333,Me2-R335,R337-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-6804379] PRMT5 binds TTC5 - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6804383
summation
[Summation:6804388] Protein arginine methyltransferase PRMT5, recruited to TP53 ...
Referrals
(hasEvent)
[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text