Reactome | SND1(1-593)-p-BRAF(381-766) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802699] p-SND1-BRAF fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-6802699] p-SND1-BRAF fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:6802551] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020788] Mondo:0005036
dbId	6802552
disease	[Disease:1500689] cancer [Disease:6802264] gastric adenocarcinoma
displayName	SND1(1-593)-p-BRAF(381-766) fusion [cytosol]
endCoordinate	593
hasModifiedResidue	[FragmentInsertionModification:6802468] Insertion of residues 381 to 766 at 594 from UniProt:P15056 BRAF [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:6800629] A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
maxDepth	1
modified	[InstanceEdit:9753817] Rothfels, Karen, 2021-09-13
name	SND1(1-593)-p-BRAF(381-766) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:Q7KZF4] UniProt:Q7KZF4 SND1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802552
startCoordinate	1
updateTrackers	[UpdateTracker:9902868] Update Tracker - [EntityWithAccessionedSequence:6802552] SND1(1-593)-p-BRAF(381-766) fusion [cytosol] - v79:[modifyName]

(updatedInstance)	[UpdateTracker:9902868] Update Tracker - [EntityWithAccessionedSequence:6802552] SND1(1-593)-p-BRAF(381-766) fusion [cytosol] - v79:[modifyName]
(hasComponent)	[Complex:R-HSA-6802699] p-SND1-BRAF fusion dimer [cytosol]

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