Reactome | BRAF V600E;V169_D380del [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802483] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105
dbId	6802486
disease	[Disease:1500689] cancer [Disease:1614289] melanoma
displayName	BRAF V600E;V169_D380del [cytosol]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802484] L-valine 600 replaced with L-glutamic acid [FragmentDeletionModification:6802485] Deletion of residues 169 to 380
inDisease	true
literatureReference	[LiteratureReference:6799060] RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
maxDepth	1
memberOf	[DefinedSet:R-HSA-6802657] V600E BRAF splice variants [cytosol] - Homo sapiens
modified	[InstanceEdit:9832454] Orlic-Milacic, Marija, 2023-04-01
name	BRAF V600E;V169_D380del
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802486
startCoordinate	2
updateTrackers	[UpdateTracker:9905615] Update Tracker - [EntityWithAccessionedSequence:6802486] BRAF V600E;V169_D380del [cytosol] - v85:[modifyName]

(updatedInstance)	[UpdateTracker:9905615] Update Tracker - [EntityWithAccessionedSequence:6802486] BRAF V600E;V169_D380del [cytosol] - v85:[modifyName]
(hasMember)	[DefinedSet:R-HSA-6802657] V600E BRAF splice variants [cytosol]

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