Reactome | FAM131B(1-18)-BRAF(381-766) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802587] FAM131B-BRAF fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-6802587] FAM131B-BRAF fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:6802324] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12021103] Mondo:0016691
dbId	6802323
disease	[Disease:6802279] pilocytic astrocytoma
displayName	FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
endCoordinate	18
hasModifiedResidue	[FragmentInsertionModification:6802322] Insertion of residues 381 to 766 at 19 from UniProt:P15056 BRAF [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729
inDisease	true
literatureReference	[LiteratureReference:6800633] Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
maxDepth	1
modified	[InstanceEdit:9753816] Rothfels, Karen, 2021-09-13
name	FAM131B(1-18)-BRAF(381-766) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:Q86XD5] UniProt:Q86XD5 FAM131B
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802323
startCoordinate	1
updateTrackers	[UpdateTracker:9902891] Update Tracker - [EntityWithAccessionedSequence:6802323] FAM131B(1-18)-BRAF(381-766) fusion [cytosol] - v79:[modifyName]

(updatedInstance)	[UpdateTracker:9902891] Update Tracker - [EntityWithAccessionedSequence:6802323] FAM131B(1-18)-BRAF(381-766) fusion [cytosol] - v79:[modifyName]
(hasComponent)	[Complex:R-HSA-6802587] FAM131B-BRAF fusion dimer [cytosol]

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