Reactome | E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression

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E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798358] Orlic-Milacic, Marija, 2015-09-18
dbId	6798353
displayName	E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:8953960] Orlic-Milacic, Marija, 2017-01-03 [InstanceEdit:8959606] Orlic-Milacic, Marija, 2017-01-27
eventOf	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6798348] E2F1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression [LiteratureReference:8953023] Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development [LiteratureReference:8953056] DNA-damage response control of E2F7 and E2F8 [LiteratureReference:8953078] E2F8 is essential for polyploidization in mammalian cells [LiteratureReference:8953070] Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer [LiteratureReference:8953005] E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression
output	[EntityWithAccessionedSequence:R-HSA-68639] E2F1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-6798356] Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641666] Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]' E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8953962] Di Stefano, Luisa, 2017-01-03 [InstanceEdit:8959604] Westendorp, Bart, 2017-01-24 [InstanceEdit:8959602] de Bruin, Alain, 2017-01-24
revised	[InstanceEdit:8953051] Orlic-Milacic, Marija, 2016-12-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6798353
summation	[Summation:6798352] Upon binding to E2F elements in the promoter of the E2F1 gen...
updateTrackers	[UpdateTracker:9781937] Update Tracker - [BlackBoxEvent:6798353] E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression - v60:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781937] Update Tracker - [BlackBoxEvent:6798353] E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression - v60:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest