E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression

Stable Identifier
R-HSA-6798353
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon binding to E2F elements in the promoter of the E2F1 gene, E2F7 represses transcription of E2F1 (Di Stefano et al. 2003, Li et al. 2008, Zalmas et al. 2008, Carvajal et al. 2012). E2F1 transcription is also directly repressed by E2F8. E2F7 and E2F8 bind to the E2F1 gene promoter as homo- or heterodimers (Li et al. 2008, Zalmas et al. 2008). E2F7- and E2F8-mediated repression of E2F1 transcription is an important step in the DNA damage induced cell cycle arrest (Zalmas et al. 2008). E2F8-mediated repression of the E2F1 gene is involved in the polyploidization of hepatocytes during liver development (Pandit et al. 2012). Loss of E2F7 and E2F8 triggers apoptosis via induction of E2F1 in response to stress (Li et al. 2008, Thurlings et al. 2016).

Literature References
PubMed ID Title Journal Year
22802528 E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, LA, Hamard, PJ, Tonnessen, C, Manfredi, JJ

Genes Dev. 2012
23064264 E2F8 is essential for polyploidization in mammalian cells

Pandit, SK, Westendorp, B, Nantasanti, S, van Liere, E, Tooten, PC, Cornelissen, PW, Toussaint, MJ, Lamers, WH, de Bruin, A

Nat. Cell Biol. 2012
18202719 DNA-damage response control of E2F7 and E2F8

Zalmas, LP, Zhao, X, Graham, AL, Fisher, R, Reilly, C, Coutts, AS, La Thangue, NB

EMBO Rep. 2008
18194653 Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development

Li, J, Ran, C, Li, E, Gordon, F, Comstock, G, Siddiqui, H, Cleghorn, W, Chen, HZ, Kornacker, K, Liu, CG, Pandit, SK, Khanizadeh, M, Weinstein, M, Leone, G, de Bruin, A

Dev. Cell 2008
27452520 Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer

Thurlings, I, Martínez-López, LM, Westendorp, B, Zijp, M, Kuiper, R, Tooten, P, Kent, LN, Leone, G, Vos, HJ, Burgering, B, de Bruin, A

Oncogene 2016
14633988 E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

Di Stefano, L, Jensen, MR, Helin, K

EMBO J. 2003
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Di Stefano, L  (2017-01-03)
Westendorp, B  (2017-01-24)
de Bruin, A  (2017-01-24)
Created
Orlic-Milacic, M  (2015-09-18)