Reactome | LIPT2 transfers octanoyl group to GCSH

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LIPT2 transfers octanoyl group to GCSH Show undefined attributes

authored	[InstanceEdit:6793592] Jassal, Bijay, 2015-09-02
catalystActivity	[CatalystActivity:6793599] lipoyl(octanoyl) transferase activity of LIPT2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:6793592] Jassal, Bijay, 2015-09-02
crossReference	[DatabaseIdentifier:9857609] RHEA:17666
dbId	6793590
displayName	LIPT2 transfers octanoyl group to GCSH
edited	[InstanceEdit:6793592] Jassal, Bijay, 2015-09-02
eventOf	[Pathway:R-HSA-9857492] Protein lipoylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6793591] LIAS synthesizes lipoyl-GCSH - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5693951] GCSH [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9857608] octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6793604] Lipoic acid synthesis and attachment in yeast mitochondria [LiteratureReference:9857614] Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy [LiteratureReference:9857595] Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death [LiteratureReference:9857610] Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis [LiteratureReference:9857803] Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	LIPT2 transfers octanoyl group to GCSH
orthologousEvent	[Reaction:R-DRE-6793590] LIPT2 transfers octanoyl group to GCSH - Danio rerio [Reaction:R-SPO-6793590] LIPT2 transfers octanoyl group to GCSH - Schizosaccharomyces pombe [Reaction:R-DDI-6793590] LIPT2 transfers octanoyl group to GCSH - Dictyostelium discoideum [Reaction:R-CEL-6793590] LIPT2 transfers octanoyl group to GCSH - Caenorhabditis elegans [Reaction:R-XTR-6793590] LIPT2 transfers octanoyl group to GCSH - Xenopus tropicalis [Reaction:R-SSC-6793590] LIPT2 transfers octanoyl group to GCSH - Sus scrofa [Reaction:R-PFA-6793590] LIPT2 transfers octanoyl group to GCSH - Plasmodium falciparum [Reaction:R-SCE-6793590] LIPT2 transfers octanoyl group to GCSH - Saccharomyces cerevisiae [Reaction:R-DME-6793590] LIPT2 transfers octanoyl group to GCSH - Drosophila melanogaster [Reaction:R-GGA-6793590] LIPT2 transfers octanoyl group to GCSH - Gallus gallus [Reaction:R-BTA-6793590] LIPT2 transfers octanoyl group to GCSH - Bos taurus [Reaction:R-CFA-6793590] LIPT2 transfers octanoyl group to GCSH - Canis familiaris [Reaction:R-RNO-6793590] LIPT2 transfers octanoyl group to GCSH - Rattus norvegicus [Reaction:R-MMU-6793590] LIPT2 transfers octanoyl group to GCSH - Mus musculus
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-163925] NDUFAB1 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-HSA-6793586] octanoyl-K107-GCSH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-6792572] LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST - Homo sapiens [Reaction:R-HSA-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14 [InstanceEdit:9861443] Hill, David P, 2024-02-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6793590
summation	[Summation:6793595] Mitochondrial lipoyltransferase 2 (LIPT2) transfers an octan...
updateTrackers	[UpdateTracker:9864209] Update Tracker - [Reaction:6793590] LIPT2 transfers octanoyl group to GCSH - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864209] Update Tracker - [Reaction:6793590] LIPT2 transfers octanoyl group to GCSH - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-9857492] Protein lipoylation
(precedingEvent)	[Reaction:R-HSA-6793591] LIAS synthesizes lipoyl-GCSH

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