Reactome | p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA

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p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA Show undefined attributes

authored	[InstanceEdit:6783726] Jupe, Steve, 2015-06-17
catalystActivity	[CatalystActivity:6785910] transmembrane receptor protein tyrosine kinase activity of IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:6784364] Jupe, Steve, 2015-06-19
dbId	6784324
displayName	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
edited	[InstanceEdit:8948388] Jupe, Steve, 2016-11-14
eventOf	[Pathway:R-HSA-6783783] Interleukin-10 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6784339] IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6783812] Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain [LiteratureReference:6783849] IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA p-Y-JAK1,p-Y-TYK2 phosphorylate IL10 dimer:2xpY-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2
orthologousEvent	[BlackBoxEvent:R-GGA-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Gallus gallus [BlackBoxEvent:R-XTR-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Xenopus tropicalis [BlackBoxEvent:R-DRE-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Danio rerio [BlackBoxEvent:R-SSC-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Sus scrofa [BlackBoxEvent:R-BTA-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Bos taurus [BlackBoxEvent:R-CFA-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Canis familiaris [BlackBoxEvent:R-RNO-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Rattus norvegicus [BlackBoxEvent:R-MMU-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-6784755] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-6784319] JAK1,TYK2 phosphorylate JAK1,TYK2 - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8937647] Meldal, Birgit, 2016-09-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6784324
summation	[Summation:6784342] Binding of IL-10 leads to activation of the receptor-associa...

Referrals

(hasEvent)	[Pathway:R-HSA-6783783] Interleukin-10 signaling
(precedingEvent)	[Reaction:R-HSA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3

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