p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA

Stable Identifier
R-HSA-6784324
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10 dimer:2xpY-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2
ReviewStatus
5/5
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p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
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Binding of IL-10 leads to activation of the receptor-associated Janus tyrosine kinases, JAK1 and TYK2 (Finbloom & Winestock 1995), leading to phosphorylation of IL10RA at two conserved intracellular tyrosine residues (Y446 and Y496) that serve as docking sites for STAT molecules (Ho et al. 1995, Weber-Nordt et al. 1996).

The details of receptor phosphorylation are unclear. Most descriptions of IL10 receptor tyrosine phosphorylation (Donnelly et al. 1999, Carey et al. 2012) suggest that JAK1 and TYK2 are responsible for IL10RA phosphorylation but it is not clear whether one or both kinases are responsible for phosphorylating IL10RA.
Literature References
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Output
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as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]

Physical Entity
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)
Authored
Jupe, S  (2015-06-17)
Reviewed
Meldal, BH  (2016-09-05)
Created
Jupe, S  (2015-06-19)
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