Reactome | TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

Schema > Reaction > Entries

TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) Show undefined attributes

authored	[InstanceEdit:6782461] May, Bruce, 2015-06-08
catalystActivity	[CatalystActivity:6782862] transferase activity, transferring alkyl or aryl (other than methyl) groups of TRMT12 [cytoplasm]
catalystActivityReference	[CatalystActivityReference:9643415] transferase activity, transferring alkyl or aryl (other than methyl) groups of TRMT12 [cytoplasm] Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA
category	transition
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:6782900] May, Bruce, 2015-06-09
dbId	6782893
displayName	TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
edited	[InstanceEdit:6782461] May, Bruce, 2015-06-08
eventOf	[Pathway:R-HSA-6782861] Synthesis of wybutosine at G37 of tRNA(Phe) - Homo sapiens
followingEvent	[Reaction:R-HSA-6782879] TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
inferredFrom	[Reaction:R-SCE-6783410] TRM12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-5279190] AdoMet [cytoplasm] [GenomeEncodedEntity:R-HSA-6782898] tRNA(Phe) containing yW-187 at 37 [cytoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6782896] Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
output	[SimpleEntity:R-ALL-5279412] MTAD [cytoplasm] [GenomeEncodedEntity:R-HSA-6782880] tRNA(Phe) containing yW-86 at 37 [cytoplasm]
precedingEvent	[Reaction:R-HSA-6782895] TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782893
summation	[Summation:6785422] As inferred from homologs in Saccharomyces cerevisiae, TRM12...

Referrals

(hasEvent)	[Pathway:R-HSA-6782861] Synthesis of wybutosine at G37 of tRNA(Phe)
(precedingEvent)	[Reaction:R-HSA-6782879] TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)
(inferredTo)	[Reaction:R-SCE-6783410] TRM12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

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