TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782893
Type
Reaction
Species
Homo sapiens
Compartment
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As inferred from homologs in Saccharomyces cerevisiae, TRM12 transfers an aminocarboxypropyl group from S-adenosymethionine to yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe), yielding yW-86 (7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine) and S-methyl-5'-thioadenosine.

Literature References
PubMed ID Title Journal Year
22761755 Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA

Rodriguez, V, Vasudevan, S, Noma, A, Carlson, BA, Green, JE, Suzuki, T, Chandrasekharappa, SC

PLoS ONE 2012
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Catalyst Activity
Catalyst Activity
Title
transferase activity, transferring alkyl or aryl (other than methyl) groups of TRMT12 [cytoplasm]
Physical Entity
Activity
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Created