Reactome | TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

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TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) Show undefined attributes

authored	[InstanceEdit:6782461] May, Bruce, 2015-06-08
catalystActivity	[CatalystActivity:6782887] tRNA (guanine(37)-N1)-methyltransferase activity of TRMT5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782900] May, Bruce, 2015-06-09
dbId	6782859
displayName	TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)
edited	[InstanceEdit:6782461] May, Bruce, 2015-06-08
eventOf	[Pathway:R-HSA-6782861] Synthesis of wybutosine at G37 of tRNA(Phe) - Homo sapiens
followingEvent	[Reaction:R-HSA-6782895] TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
inferredFrom	[Reaction:R-SCE-6783396] TRM5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [GenomeEncodedEntity:R-HSA-6782877] tRNA(Phe) containing G-37 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6783434] Conservation of structure and mechanism by Trm5 enzymes [LiteratureReference:6783403] Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [GenomeEncodedEntity:R-HSA-6783390] tRNA(Phe) containing 1-methylG-37 [nucleoplasm]
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782859
summation	[Summation:6785408] TRMT5 transfers a methyl group from S-adenosylmethionine to ...

Referrals

(hasEvent)	[Pathway:R-HSA-6782861] Synthesis of wybutosine at G37 of tRNA(Phe)
(precedingEvent)	[Reaction:R-HSA-6782895] TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
(inferredTo)	[Reaction:R-SCE-6783396] TRM5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

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