Reactome | NSF ATPase activity dissociates cis-SNARE

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NSF ATPase activity dissociates cis-SNARE Show undefined attributes

authored	[InstanceEdit:5688242] Rothfels, Karen, 2015-04-14
catalystActivity	[CatalystActivity:5694354] ATP hydrolysis activity of cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane]
category	transition
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:5694424] Rothfels, Karen, 2015-05-21
dbId	5694425
displayName	NSF ATPase activity dissociates cis-SNARE
edited	[InstanceEdit:5688570] Rothfels, Karen, 2015-04-17
eventOf	[Pathway:R-HSA-204005] COPII-mediated vesicle transport - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5694312] cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5688473] Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles [LiteratureReference:5688485] An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion [LiteratureReference:5688502] Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion [LiteratureReference:5688488] Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles [LiteratureReference:5688492] Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor [LiteratureReference:5688493] NSF N-terminal domain crystal structure: models of NSF function [LiteratureReference:5688498] Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) [LiteratureReference:5688507] Three ?SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF) [LiteratureReference:5688193] Membrane fusion: grappling with SNARE and SM proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NSF ATPase activity dissociates cis-SNARE
output	[EntityWithAccessionedSequence:R-HSA-5688142] BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] [CandidateSet:R-HSA-5694306] ER-to-ERGIC v-SNARES [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-HSA-535472] GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Complex:R-HSA-2193131] NSF hexamer [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-HSA-5688147] SCFD1 [cytosol] 3 × [CandidateSet:R-HSA-5694313] SNAPs [cytosol] [CandidateSet:R-HSA-6807784] STX5,17 [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-5694423] NSF and SNAPs bind cis-SNARE complex - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791049] Gillespie, Marc E, 2015-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5694425
summation	[Summation:5694378] NSF-dependent hydrolysis of ATP is required to disassociate ...
updateTrackers	[UpdateTracker:9783960] Update Tracker - [Reaction:5694425] NSF ATPase activity dissociates cis-SNARE - v55:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783960] Update Tracker - [Reaction:5694425] NSF ATPase activity dissociates cis-SNARE - v55:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-204005] COPII-mediated vesicle transport

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