Reactome | UCHL3, SENP8 cleave NEDD8

Schema > Reaction > Entries

UCHL3, SENP8 cleave NEDD8 Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:5690813] deNEDDylase activity of UCHL3,SENP8:NEDD8(1-88) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5690772] Jupe, Steve, 2015-04-30
dbId	5690808
displayName	UCHL3, SENP8 cleave NEDD8
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens [Pathway:R-HSA-5689603] UCH proteinases - Homo sapiens
followingEvent	[Reaction:R-HSA-8951644] Release of mature NEDD8 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6782635] UCHL3,SENP8:NEDD8(1-88) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6783443] Cleavage of the C-terminus of NEDD8 by UCH-L3
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UCHL3, SENP8 cleave NEDD8
orthologousEvent	[Reaction:R-PFA-5690808] UCHL3, SENP8 cleave NEDD8 - Plasmodium falciparum [Reaction:R-SCE-5690808] UCHL3, SENP8 cleave NEDD8 - Saccharomyces cerevisiae [Reaction:R-SPO-5690808] UCHL3, SENP8 cleave NEDD8 - Schizosaccharomyces pombe [Reaction:R-DDI-5690808] UCHL3, SENP8 cleave NEDD8 - Dictyostelium discoideum [Reaction:R-CEL-5690808] UCHL3, SENP8 cleave NEDD8 - Caenorhabditis elegans [Reaction:R-DME-5690808] UCHL3, SENP8 cleave NEDD8 - Drosophila melanogaster [Reaction:R-GGA-5690808] UCHL3, SENP8 cleave NEDD8 - Gallus gallus [Reaction:R-XTR-5690808] UCHL3, SENP8 cleave NEDD8 - Xenopus tropicalis [Reaction:R-DRE-5690808] UCHL3, SENP8 cleave NEDD8 - Danio rerio [Reaction:R-SSC-5690808] UCHL3, SENP8 cleave NEDD8 - Sus scrofa [Reaction:R-BTA-5690808] UCHL3, SENP8 cleave NEDD8 - Bos taurus [Reaction:R-CFA-5690808] UCHL3, SENP8 cleave NEDD8 - Canis familiaris [Reaction:R-RNO-5690808] UCHL3, SENP8 cleave NEDD8 - Rattus norvegicus [Reaction:R-MMU-5690808] UCHL3, SENP8 cleave NEDD8 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-6782654] NEDD8(77-81) [cytosol] [Complex:R-HSA-6782643] UCHL3,SENP8:NEDD8 [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690808
summation	[Summation:5690814] UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NE...

Referrals

(hasEvent)	[Pathway:R-HSA-5689603] UCH proteinases [Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8951644] Release of mature NEDD8