Reactome | UCHL1, UCHL3 cleave ubiquitin adducts

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UCHL1, UCHL3 cleave ubiquitin adducts Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:5690781] cysteine-type deubiquitinase activity of UCHL1,UCHL3:Ub-Lys [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5690302] Jupe, Steve, 2015-04-28
dbId	5690319
displayName	UCHL1, UCHL3 cleave ubiquitin adducts
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5689603] UCH proteinases - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6782633] UCHL1,UCHL3:Ub-Lys [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690757] The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase [LiteratureReference:6783443] Cleavage of the C-terminus of NEDD8 by UCH-L3
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UCHL1, UCHL3 cleave ubiquitin adducts
orthologousEvent	[Reaction:R-PFA-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Plasmodium falciparum [Reaction:R-DDI-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Dictyostelium discoideum [Reaction:R-CEL-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Caenorhabditis elegans [Reaction:R-DME-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Drosophila melanogaster [Reaction:R-GGA-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Gallus gallus [Reaction:R-XTR-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Xenopus tropicalis [Reaction:R-DRE-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Danio rerio [Reaction:R-SSC-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Sus scrofa [Reaction:R-BTA-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Bos taurus [Reaction:R-CFA-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Canis familiaris [Reaction:R-RNO-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Rattus norvegicus [Reaction:R-MMU-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Mus musculus
output	[SimpleEntity:R-ALL-1131871] L-lysine [cytoplasm] [Complex:R-HSA-6782592] UCHL1,UCHL3:Ub [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690319
summation	[Summation:5690317] UCHL1 and UCHL3 can hydrolyze several short C-terminal ubiqu...

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(hasEvent)

[Pathway:R-HSA-5689603] UCH proteinases