Reactome | p-S MAPKAPK5 phosphorylates HSPB1

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p-S MAPKAPK5 phosphorylates HSPB1 Show undefined attributes

authored	[InstanceEdit:5685867] Rothfels, Karen, 2015-03-30
catalystActivity	[CatalystActivity:5687074] protein serine/threonine kinase activity of p-S MAPKAPK5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5687122] Rothfels, Karen, 2015-04-06
dbId	5687121
displayName	p-S MAPKAPK5 phosphorylates HSPB1
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-450563] HSPB1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686799] Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology [LiteratureReference:3238986] PRAK is essential for ras-induced senescence and tumor suppression [LiteratureReference:5686748] 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization [LiteratureReference:5686819] Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5 [LiteratureReference:3239000] PRAK, a novel protein kinase regulated by the p38 MAP kinase [LiteratureReference:5686768] Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway [LiteratureReference:5686834] PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5 [LiteratureReference:5686957] Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function [LiteratureReference:5686970] Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5 [LiteratureReference:5686857] Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 [LiteratureReference:5686804] IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling [LiteratureReference:5218452] Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27 [LiteratureReference:5686791] HSPB1, actin filament dynamics, and aging cells [LiteratureReference:5686792] Heat shock protein 27 phosphorylation state is associated with cancer progression [LiteratureReference:5218358] Endothelial cell migration during angiogenesis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-S MAPKAPK5 phosphorylates HSPB1
orthologousEvent	[Reaction:R-GGA-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Gallus gallus [Reaction:R-DRE-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Danio rerio [Reaction:R-SSC-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Sus scrofa [Reaction:R-BTA-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Bos taurus [Reaction:R-RNO-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Rattus norvegicus [Reaction:R-MMU-5687121] p-S MAPKAPK5 phosphorylates HSPB1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-5687009] p-S78,S82 HSPB1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5687120] p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-5687123] p-S115 MAPKAPK5 translocates to the cytosol - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687121
summation	[Summation:5686865] HSBP1, also known as HSP27, is small actin-binding protein w...

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(hasEvent)

[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling

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