p-S MAPKAPK5 phosphorylates HSPB1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HSBP1, also known as HSP27, is small actin-binding protein with roles in cytoskeletal regulation as well as other processes. HSBP1 is a substrate for MAPKAPK5 both in vitro and in vivo, and phosphorylation of serine residues stimulates forskolin-induced F-actin rearrangements (Sun et al, 2007; Tak et al, 2007; Gerits et al, 2007; New et al, 1998; Seternes et al, 2004; Kostenko et al, 2009a; Kostenko et al, 2009b; Kostenko et al, 2011a; reviewed in Kostenko et al, 2011b; Kostenko et al, 2012). There are divergent reports about the physiological relevance of HSBP1 phosphorylation on actin polymeriztion and cell motility (Lavoie et al, 1995; Lamalice et al, 2007; Katsogiannou et al, 2014; Rousseau et al, 2000; Doshi et al, 2010; Stohr et al, 2012). Actin cytoskeletal rearrangements through the MAPK4 pathway are controlled in part by the IGF2BP1-mediated downregulation of MAPK4 translation which abrogates MAPKAPK5 activity and HSBP1 phosphorylation (Stohr et al, 2012).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
25339975 Heat shock protein 27 phosphorylation state is associated with cancer progression

Andrieu, C, Katsogiannou, M, Rocchi, P

Front Genet 2014
7799959 Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

Weber, LA, Lavoie, JN, Lambert, H, Landry, J, Hickey, E

Mol. Cell. Biol. 1995
20734105 Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function

Dumitriu, G, Klenow, H, Kostenko, S, Moens, U, Johannessen, M, Gerits, N, Shiryaev, A

Cell. Mol. Life Sci. 2011
17254968 PRAK is essential for ras-induced senescence and tumor suppression

Li, Y, Yamout, M, Sun, P, Frangou, CG, Yates, JR, Liao, R, Wright, PE, Yoshizuka, N, Deng, Q, Dong, MQ, Xie, C, Chen, J, Han, J, New, L, Moser, BA

Cell 2007
17395884 Endothelial cell migration during angiogenesis

Le Boeuf, F, Huot, J, Lamalice, L

Circ. Res. 2007
19593530 Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

Kostenko, S, Moens, U

Cell. Mol. Life Sci. 2009
17947239 Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5

Kostenko, S, Mikalsen, T, Moens, U, Johannessen, M, Gerits, N, Shiryaev, A

J. Biol. Chem. 2007
20536836 HSPB1, actin filament dynamics, and aging cells

Hightower, LE, Lee, J, Doshi, BM

Ann. N. Y. Acad. Sci. 2010
20849292 Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5

Dumitriu, G, Kostenko, S, Moens, U, Gerits, N, Shiryaev, A

J. Recept. Signal Transduct. Res. 2011
17728103 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization

Ahn, JK, Yoon, YS, Kim, SB, Lee, JH, Tak, H, Suk, J, Jang, E, Joe, CO, Park, J

Cell. Signal. 2007
9628874 PRAK, a novel protein kinase regulated by the p38 MAP kinase

Kato, Y, Zhu, W, Han, J, Liu, K, Flood, LJ, Zhao, M, Jiang, Y, Parry, GC, New, L

EMBO J. 1998
15577943 Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

Meloche, S, Johansen, B, Morrice, NA, Mikalsen, T, Moens, U, Armstrong, CG, Keyse, SM, Turgeon, B, Michaelsen, E, Seternes, OM

EMBO J. 2004
19166925 PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

Kostenko, S, Moens, U, Johannessen, M

Cell. Signal. 2009
22279049 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling

Glass, M, Stöhr, N, Lederer, M, Singer, RH, Hüttelmaier, S, Reinke, C, Köhn, M

Genes Dev. 2012
Catalyst Activity

protein serine/threonine kinase activity of p-S MAPKAPK5 [cytosol]

Orthologous Events
Cite Us!