Reactome | MUS81:EME1,EME2 cleaves D-loop

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MUS81:EME1,EME2 cleaves D-loop Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5686450] DNA endonuclease activity of MUS81:EME1, (MUS81:EME2) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686429] Orlic-Milacic, Marija, 2015-04-01
dbId	5686440
displayName	MUS81:EME1,EME2 cleaves D-loop
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 - Homo sapiens
input	[Complex:R-HSA-5686104] Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686444] Substrate specificity of the MUS81-EME2 structure selective endonuclease [LiteratureReference:5686470] Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair [LiteratureReference:5686461] Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	MUS81:EME1,EME2 cleaves D-loop
orthologousEvent	[Reaction:R-XTR-5686440] MUS81:EME1,EME2 cleaves D-loop - Xenopus tropicalis [Reaction:R-DRE-5686440] MUS81:EME1,EME2 cleaves D-loop - Danio rerio [Reaction:R-SSC-5686440] MUS81:EME1,EME2 cleaves D-loop - Sus scrofa [Reaction:R-BTA-5686440] MUS81:EME1,EME2 cleaves D-loop - Bos taurus [Reaction:R-CFA-5686440] MUS81:EME1,EME2 cleaves D-loop - Canis familiaris [Reaction:R-RNO-5686440] MUS81:EME1,EME2 cleaves D-loop - Rattus norvegicus [Reaction:R-MMU-5686440] MUS81:EME1,EME2 cleaves D-loop - Mus musculus
output	[Complex:R-HSA-5686432] Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5686430] MUS81 binds EME1, EME2 - Homo sapiens [Reaction:R-HSA-5693593] D-loop extension by DNA polymerases - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5686440
summation	[Summation:5686456] The complex of MUS81 and EME1 or EME2 acts as an endonucleas...

Referrals

(hasEvent)	[Pathway:R-HSA-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates
(precedingEvent)	[BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2