MUS81:EME1,EME2 cleaves D-loop

Stable Identifier
R-HSA-5686440
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of MUS81 and EME1 or EME2 acts as an endonuclease and processes D-loops by cleaving the sister chromatid strand complementary to the invading strand at the junction point. MUS81:EME2 complex has a higher catalytic activity than MUS81:EME1 complex and, in vitro, cleaves D-loops at several other sites in addition to the junction point (Osman et al. 2003, Pepe and West 2014). The yeast Mus81:Eme1 (Mus81:Mms4) complex also acts on D-loops (Schwartz et al. 2012).

Literature References
PubMed ID Title Journal Year
14527420 Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis

Doe, CL, Osman, F, Whitby, MC, Dixon, J

Mol. Cell 2003
24371268 Substrate specificity of the MUS81-EME2 structure selective endonuclease

West, SC, Pepe, A

Nucleic Acids Res. 2014
22645308 Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair

Heyer, WD, Wright, WD, Stahlberg, H, Schwartz, EK, Evans, JE, Ehmsen, KT

Mol. Cell. Biol. 2012
Participants
Participates
Catalyst Activity

endodeoxyribonuclease activity of MUS81:EME1, (MUS81:EME2) [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!