Reactome | CSF2RA:CSF2RB binds SFTPs

Schema > Reaction > Entries

CSF2RA:CSF2RB binds SFTPs Show undefined attributes

authored	[InstanceEdit:5686308] Jassal, Bijay, 2015-04-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5686360] Jassal, Bijay, 2015-04-01
dbId	5686335
diseaseReaction	[FailedReaction:R-HSA-5688899] Defective CSF2RA does not bind SFTPs - Homo sapiens [FailedReaction:R-HSA-5688884] Defective CSF2RB does not bind SFTPs - Homo sapiens
displayName	CSF2RA:CSF2RB binds SFTPs
edited	[InstanceEdit:5686308] Jassal, Bijay, 2015-04-01
eventOf	[Pathway:R-HSA-5683826] Surfactant metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-5686359] SFTPs translocate from extracellular region to clathrin-coated vesicle - Homo sapiens
input	[Complex:R-HSA-5686355] CSF2RA:CSF2RB [plasma membrane] [DefinedSet:R-HSA-5685647] SFTPAs [extracellular region] [Complex:R-HSA-6792856] SFTPB dimer [extracellular region] [EntityWithAccessionedSequence:R-HSA-5683685] SFTPC [extracellular region] [Complex:R-HSA-5686241] SFTPD 12mer [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686352] The molecular basis of pulmonary alveolar proteinosis [LiteratureReference:5686350] Pathways for clearance of surfactant protein A from the lung [LiteratureReference:5686299] Surfactant catabolism [LiteratureReference:913385] The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	CSF2RA:CSF2RB binds SFTPs
orthologousEvent	[Reaction:R-BTA-5686335] CSF2RA:CSF2RB binds SFTPs - Bos taurus [Reaction:R-CFA-5686335] CSF2RA:CSF2RB binds SFTPs - Canis familiaris
output	[Complex:R-HSA-5686345] CSF2RA:CSF2RB:SFTPs [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5685649] SFTPAs translocate from ER membrane to extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-5684862] SFTPB,C, PC, PG translocate from lamellar body to extracellular region - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791021] D'Eustachio, Peter, 2015-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5686335
summation	[Summation:5686366] Surfactant catabolism by alveolar macrophages plays a small ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5688899] Defective CSF2RA does not bind SFTPs [FailedReaction:R-HSA-5688884] Defective CSF2RB does not bind SFTPs
(hasEvent)	[Pathway:R-HSA-5683826] Surfactant metabolism
(precedingEvent)	[Reaction:R-HSA-5686359] SFTPs translocate from extracellular region to clathrin-coated vesicle