Reactome | CHEK1 is recruited to resected DNA DSBs

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CHEK1 is recruited to resected DNA DSBs Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684884] Orlic-Milacic, Marija, 2015-03-23
dbId	5684882
displayName	CHEK1 is recruited to resected DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs - Homo sapiens
input	[Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-113826] CHEK1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-176296] p-T916,S945-CLSPN [nucleoplasm] [Complex:R-HSA-5684985] TIMELESS:TIPIN [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685010] Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress [LiteratureReference:5685045] Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1 [LiteratureReference:176239] DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system [LiteratureReference:176194] Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 [LiteratureReference:5685054] Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress [LiteratureReference:5685173] Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CHEK1 is recruited to resected DNA DSBs
negativePrecedingEvent	[NegativePrecedingEvent:9766946] Futile Cycle: Activation of CHEK1 at resected DNA DSBs
orthologousEvent	[Reaction:R-GGA-5684882] CHEK1 is recruited to resected DNA DSBs - Gallus gallus [Reaction:R-SSC-5684882] CHEK1 is recruited to resected DNA DSBs - Sus scrofa [Reaction:R-CFA-5684882] CHEK1 is recruited to resected DNA DSBs - Canis familiaris [Reaction:R-RNO-5684882] CHEK1 is recruited to resected DNA DSBs - Rattus norvegicus [Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs - Mus musculus
output	[Complex:R-HSA-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5685156] ATR phosphorylates RPA2 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684882
summation	[Summation:5685043] The recruitment of CHEK1 (CHK1) to resected DNA double-stran...
updateTrackers	[UpdateTracker:9775713] Update Tracker - [Reaction:5684882] CHEK1 is recruited to resected DNA DSBs - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775713] Update Tracker - [Reaction:5684882] CHEK1 is recruited to resected DNA DSBs - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs

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