Reactome | NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]

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NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] Show undefined attributes

catalystActivities	[CatalystActivity:5668645] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
compartment	[Compartment:1222693] phagocytic vesicle membrane
componentOf	[Complex:R-HSA-9626792] NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9626848] S100A8:S100A9:AA:Ca(2+) binds NOX2 complex - Homo sapiens
created	[InstanceEdit:5668602] Orlic-Milacic, Marija, 2015-01-26
dbId	5668618
displayName	NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
hasComponent	[Complex:R-HSA-1996217] NOX2 complex [phagocytic vesicle membrane] [Complex:R-HSA-5668609] RAC2:GTP [phagocytic vesicle membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:263698] phagolysosome
inferredTo	[Complex:R-MMU-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Mus musculus [Complex:R-RNO-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Rattus norvegicus [Complex:R-CFA-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Canis familiaris [Complex:R-BTA-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Bos taurus [Complex:R-SSC-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Sus scrofa [Complex:R-DRE-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Danio rerio [Complex:R-XTR-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Xenopus tropicalis [Complex:R-GGA-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:5668623] Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 [LiteratureReference:5668616] Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways [LiteratureReference:5668610] Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
maxDepth	4
name	NOX2 complex:RAC2:GTP
producedByEvent	[Reaction:R-HSA-5668605] RAC2:GTP binds NOX2 complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5668618

Referrals

(input)	[Reaction:R-HSA-9626848] S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
(hasComponent)	[Complex:R-HSA-9626792] NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]
(physicalEntity)	[CatalystActivity:5668645] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
(output)	[Reaction:R-HSA-5668605] RAC2:GTP binds NOX2 complex

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