Reactome | ALKBH2 binds alkylated dsDNA containing 3-meC

Schema > Reaction > Entries

ALKBH2 binds alkylated dsDNA containing 3-meC Show undefined attributes

authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15
dbId	5657665
displayName	ALKBH2 binds alkylated dsDNA containing 3-meC
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
eventOf	[Pathway:R-HSA-112122] ALKBH2 mediated reversal of alkylation damage - Homo sapiens
followingEvent	[Reaction:R-HSA-112120] Oxidative demethylation of 3-meC damaged DNA by ALKBH2 - Homo sapiens
input	[GenomeEncodedEntity:R-HSA-5657603] 3-meC-dsDNA [nucleoplasm] [Complex:R-HSA-5656464] ALKBH2:Fe2+ [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:113684] Reversal of DNA alkylation damage by two human dioxygenases. [LiteratureReference:5657645] Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA [LiteratureReference:5657644] Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALKBH2 binds alkylated dsDNA containing 3-meC
output	[Complex:R-HSA-5657613] ALKBH2:Fe2+:3-meC-dsDNA [nucleoplasm]
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5657665
summation	[Summation:5657656] ALKBH2 binds alkylated DNA containing 3-methylcytosine (3-me...

Referrals

(precedingEvent)	[Reaction:R-HSA-112120] Oxidative demethylation of 3-meC damaged DNA by ALKBH2
(hasEvent)	[Pathway:R-HSA-112122] ALKBH2 mediated reversal of alkylation damage

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