ALKBH2 binds alkylated dsDNA containing 3-meC

Stable Identifier
R-HSA-5657665
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ALKBH2 binds alkylated dsDNA containing 3-meC
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ALKBH2 binds alkylated DNA containing 3-methylcytosine (3-meC). ALKBH2 preferentially binds double strand DNA (dsDNA) (Duncan et al. 2002, Aas et al. 2003, Chen et al. 2010). Iron (Fe2+) is needed for the catalytic activity of ALKBH2 (Duncan et al. 2002).
Literature References
PubMed ID Title Journal Year
12594517 Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

Falnes, PO, Otterlei, M, Seeberg, E, Akbari, M, Slupphaug, G, Vågbø, CB, Bjørås, M, Skorpen, F, Aas, PA, Sundheim, O, Krokan, HE

Nature 2003
20714506 Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3

Sun, X, Chen, B, Liu, H, Yang, CG

Mol Biosyst 2010
12486230 Reversal of DNA alkylation damage by two human dioxygenases.

Lindahl, T, Duncan, T, Bates, PA, Sedgwick, B, Trewick, SC, Koivisto, P

Proc Natl Acad Sci U S A 2002
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Authored
Pegg, AE  (2004-02-04)
Reviewed
Joshi-Tope, G  (2004-02-04)
Gillespie, ME  (2015-02-06)
Created
Orlic-Milacic, M  (2014-12-16)
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