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Schema
>
FailedReaction
>
Entries
Defective KHK does not phosphorylate beta-D-fructose
Show undefined attributes
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authored
[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
catalystActivity
[CatalystActivity:9631854] ketohexokinase activity of KHK mutant dimers [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5656453] D'Eustachio, Peter, 2014-12-12
crossReference
[DatabaseIdentifier:12020935] Mondo:0019214
dbId
5656459
disease
[Disease:5656463] carbohydrate metabolic disorder
displayName
Defective KHK does not phosphorylate beta-D-fructose
edited
[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
entityFunctionalStatus
[EntityFunctionalStatus:5656461] loss_of_function of KHK mutant dimers [cytosol]
eventOf
[Pathway:R-HSA-5657562] Essential fructosuria - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29532] Fru [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5652057] Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria
[LiteratureReference:469711] Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase)
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Defective KHK does not phosphorylate beta-D-fructose
normalReaction
[Reaction:R-HSA-70333] KHK dimer phosphorylates Fru to Fru 1-P
releaseDate
2015-03-19
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5675821] Timson, David J, Tolan, Dean R, 2015-02-16
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5656459
summation
[Summation:5656439] Variant KHK (ketohexokinase) protein fails to catalyze the p...
updateTrackers
[UpdateTracker:9778468] Update Tracker - [FailedReaction:5656459] Defective KHK does not phosphorylate beta-D-fructose - v68:[addCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9778468] Update Tracker - [FailedReaction:5656459] Defective KHK does not phosphorylate beta-D-fructose - v68:[addCatalystActivity]
(hasEvent)
[Pathway:R-HSA-5657562] Essential fructosuria
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