Reactome | CBL ubiquitinates FRS2 and FGFR2

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CBL ubiquitinates FRS2 and FGFR2 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654676] ubiquitin protein ligase activity of Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643276] ubiquitin protein ligase activity of Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654678] Rothfels, Karen, 2014-12-03
dbId	5654677
deleted	[Deleted:5655527] Deletion of instance: 1270444
displayName	CBL ubiquitinates FRS2 and FGFR2
eventOf	[Pathway:R-HSA-5654727] Negative regulation of FGFR2 signaling - Homo sapiens
input	[Complex:R-HSA-5654286] Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl [LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CBL ubiquitinates FRS2 and FGFR2
orthologousEvent	[Reaction:R-MMU-5654677] CBL ubiquitinates FRS2 and FGFR2 - Mus musculus [Reaction:R-CEL-5654677] CBL ubiquitinates FRS2 and FGFR2 - Caenorhabditis elegans [Reaction:R-DME-5654677] CBL ubiquitinates FRS2 and FGFR2 - Drosophila melanogaster [Reaction:R-GGA-5654677] CBL ubiquitinates FRS2 and FGFR2 - Gallus gallus [Reaction:R-XTR-5654677] CBL ubiquitinates FRS2 and FGFR2 - Xenopus tropicalis [Reaction:R-DRE-5654677] CBL ubiquitinates FRS2 and FGFR2 - Danio rerio [Reaction:R-SSC-5654677] CBL ubiquitinates FRS2 and FGFR2 - Sus scrofa [Reaction:R-BTA-5654677] CBL ubiquitinates FRS2 and FGFR2 - Bos taurus [Reaction:R-CFA-5654677] CBL ubiquitinates FRS2 and FGFR2 - Canis familiaris [Reaction:R-RNO-5654677] CBL ubiquitinates FRS2 and FGFR2 - Rattus norvegicus
output	[Complex:R-HSA-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654729] p-CBL:GRB2 binds p-FRS2:activated FGFR2 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654677
summation	[Summation:191560] Grb2 bound to tyrosine phosphorylated FRS2 forms a ternary c...

Referrals

(replacementInstances)	[Deleted:5655527] Deletion of instance: 1270444
(hasEvent)	[Pathway:R-HSA-5654727] Negative regulation of FGFR2 signaling