Reactome | Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]

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Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654359] Rothfels, Karen, 2014-12-03
dbId	5654360
displayName	Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]
hasComponent	[Complex:R-HSA-5654286] Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Mus musculus [Complex:R-RNO-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Canis familiaris [Complex:R-BTA-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Bos taurus [Complex:R-SSC-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Sus scrofa [Complex:R-DRE-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Danio rerio [Complex:R-XTR-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Gallus gallus [Complex:R-DME-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
maxDepth	9
name	Ub-Activated FGFR2 complex:Ub-p-FRS2
producedByEvent	[Reaction:R-HSA-5654677] CBL ubiquitinates FRS2 and FGFR2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5654360
updateTrackers	[UpdateTracker:9893416] Update Tracker - [Complex:5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - v56:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9893416] Update Tracker - [Complex:5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] - v56:[updateContainedComponent]
(output)	[Reaction:R-HSA-5654677] CBL ubiquitinates FRS2 and FGFR2

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