Reactome | Activated FGFR1 phosphorylates SHC1

Schema > Reaction > Entries

Activated FGFR1 phosphorylates SHC1 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654580] protein tyrosine kinase activity of Activated FGFR1:SHC1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654581] Rothfels, Karen, 2014-12-03
dbId	5654582
deleted	[Deleted:5655548] Deletion of instance: 1268281
displayName	Activated FGFR1 phosphorylates SHC1
eventOf	[Pathway:R-HSA-5654688] SHC-mediated cascade:FGFR1 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 - Homo sapiens
input	[Complex:R-HSA-5654258] Activated FGFR1:SHC1 [plasma membrane] 3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:532248] Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) [LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:532255] Fibroblast growth factor receptors have different signaling and mitogenic potentials
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR1 phosphorylates SHC1
orthologousEvent	[Reaction:R-DME-5654582] Activated FGFR1 phosphorylates SHC1 - Drosophila melanogaster [Reaction:R-GGA-5654582] Activated FGFR1 phosphorylates SHC1 - Gallus gallus [Reaction:R-XTR-5654582] Activated FGFR1 phosphorylates SHC1 - Xenopus tropicalis [Reaction:R-DRE-5654582] Activated FGFR1 phosphorylates SHC1 - Danio rerio [Reaction:R-SSC-5654582] Activated FGFR1 phosphorylates SHC1 - Sus scrofa [Reaction:R-BTA-5654582] Activated FGFR1 phosphorylates SHC1 - Bos taurus [Reaction:R-CFA-5654582] Activated FGFR1 phosphorylates SHC1 - Canis familiaris [Reaction:R-RNO-5654582] Activated FGFR1 phosphorylates SHC1 - Rattus norvegicus [Reaction:R-MMU-5654582] Activated FGFR1 phosphorylates SHC1 - Mus musculus
output	[Complex:R-HSA-5654273] Activated FGFR1:p-SHC1 [plasma membrane] 3 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654582
summation	[Summation:1268280] The p46 and p53 isoforms of SHC1 have been shown to be phosp...

Referrals

(replacementInstances)	[Deleted:5655548] Deletion of instance: 1268281
(hasEvent)	[Pathway:R-HSA-5654688] SHC-mediated cascade:FGFR1
(precedingEvent)	[Reaction:R-HSA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1