Activated FGFR1 phosphorylates SHC1

Stable Identifier
R-HSA-5654582
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The p46 and p53 isoforms of SHC1 have been shown to be phosphorylated upon FGF stimulation. Three consensus RTK phosphoryation sites are present in SHC1, although phosphorylation of these specific tyrosine residues has not been explicitly demonstrated in response to FGF stimulation. In contrast, the p66 isoform of SHC1 does not appear to undergo FGF-dependent phosphorylation.

Literature References
PubMed ID Title Journal Year
8264585 Fibroblast growth factor receptors have different signaling and mitogenic potentials

Wang, JK, Gao, G, Goldfarb, M

Mol Cell Biol 1994
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Klint, P, Kanda, S, Claesson-Welsh, L

J Biol Chem 1995
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
18840094 Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)

Schüller, AC, Ahmed, Z, Levitt, JA, Suen, KM, Suhling, K, Ladbury, JE

Biochem J 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated FGFR1:SHC1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created