Activated FGFR1 phosphorylates SHC1

Stable Identifier
R-HSA-5654582
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The p46 and p53 isoforms of SHC1 have been shown to be phosphorylated upon FGF stimulation. Three consensus RTK phosphoryation sites are present in SHC1, although phosphorylation of these specific tyrosine residues has not been explicitly demonstrated in response to FGF stimulation. In contrast, the p66 isoform of SHC1 does not appear to undergo FGF-dependent phosphorylation.
Literature References
PubMed ID Title Journal Year
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Kanda, S, Klint, P, Claesson-Welsh, L

J Biol Chem 1995
8264585 Fibroblast growth factor receptors have different signaling and mitogenic potentials

Wang, JK, Goldfarb, M, Gao, G

Mol Cell Biol 1994
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
18840094 Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)

Suhling, K, Levitt, JA, Ladbury, JE, Suen, KM, Ahmed, Z, Schüller, AC

Biochem J 2008
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR1:SHC1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!