Reactome | Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2

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Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654567] Rothfels, Karen, 2014-12-03
dbId	5654566
deleted	[Deleted:5655531] Deletion of instance: 1270466
displayName	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
eventOf	[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling - Homo sapiens
input	[Complex:R-HSA-5654182] Activated FGFR4:FRS2 [plasma membrane] 8 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors [LiteratureReference:1268119] FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway [LiteratureReference:1268116] EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2 [LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
orthologousEvent	[Reaction:R-CEL-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Caenorhabditis elegans [Reaction:R-DME-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Drosophila melanogaster [Reaction:R-GGA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Gallus gallus [Reaction:R-XTR-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Xenopus tropicalis [Reaction:R-DRE-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Danio rerio [Reaction:R-SSC-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Sus scrofa [Reaction:R-BTA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Bos taurus [Reaction:R-CFA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Canis familiaris [Reaction:R-RNO-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Rattus norvegicus [Reaction:R-MMU-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Mus musculus
output	[Complex:R-HSA-5654322] Activated FGFR4:p-8T-FRS2 [plasma membrane] 8 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654566
summation	[Summation:1268241] FRS2 has 8 canonical MAPK phosphorylation sites which are ph...

Referrals

(replacementInstances)	[Deleted:5655531] Deletion of instance: 1270466
(hasEvent)	[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling