FRS2 has 8 canonical MAPK phosphorylation sites which are ph...

created [InstanceEdit:1268242] Rothfels, K, 2011-05-09
dbId 1268241
displayName FRS2 has 8 canonical MAPK phosphorylation sites which are ph...
modified [InstanceEdit:5654385] Rothfels, Karen, 2014-12-03
schemaClass Summation
text FRS2 has 8 canonical MAPK phosphorylation sites which are phosphorylated by activated ERK1/2 after FGF stimulation. Phosphorylation of these 8 threonine residues counteracts the activating effect of tyrosine phosphorylation of FRS2, although the exact mechanism for this negative regulation is not known. Expression of a version of FRS2 in which the 8 threonine residues are mutated to valine results in enhanced tyrosine phosphorylation of FRS2, enhanced GRB2-SOS1 recruitment and a more sustained MAPK response. The 8 threonine residues are not conserved in FRS3; as a result, signaling through FRS3 complexes do not appear to be subject to this downregulation.
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