Reactome | KAL1 binds FGFR1c

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KAL1 binds FGFR1c Show undefined attributes

authored	[InstanceEdit:5653741] Rothfels, Karen, 2014-12-01
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654516] Rothfels, Karen, 2014-12-03
dbId	5654514
displayName	KAL1 binds FGFR1c
edited	[InstanceEdit:5662959] Rothfels, Karen, 2015-01-14
eventOf	[Pathway:R-HSA-5654726] Negative regulation of FGFR1 signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-189897] FGFR1c [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5654345] KAL1 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5654104] Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1 [LiteratureReference:5653998] Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator [LiteratureReference:5653990] Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific manner [LiteratureReference:5654011] Novel insights in FGFR1 regulation: lessons from Kallmann syndrome [LiteratureReference:5654100] Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome [LiteratureReference:5654103] Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes [LiteratureReference:5654002] Kallmann syndrome [LiteratureReference:5654007] Molecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1 [LiteratureReference:5653989] Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [LiteratureReference:5654022] The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KAL1 binds FGFR1c
orthologousEvent	[Reaction:R-SSC-5654514] KAL1 binds FGFR1c - Sus scrofa [Reaction:R-CEL-5654514] KAL1 binds FGFR1c - Caenorhabditis elegans [Reaction:R-DME-5654514] KAL1 binds FGFR1c - Drosophila melanogaster [Reaction:R-GGA-5654514] KAL1 binds FGFR1c - Gallus gallus [Reaction:R-XTR-5654514] KAL1 binds FGFR1c - Xenopus tropicalis [Reaction:R-DRE-5654514] KAL1 binds FGFR1c - Danio rerio [Reaction:R-CFA-5654514] KAL1 binds FGFR1c - Canis familiaris
output	[Complex:R-HSA-5654346] FGFR1c:KAL1 [plasma membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851383] Nishimura, Tatsunori, 2016-01-06 [InstanceEdit:8851378] Grose, Richard P, 2016-01-06 [InstanceEdit:8865033] Gotoh, N, 2016-03-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654514
summation	[Summation:5654373] KAL1 is an extracellular matrix-associated protein that modu...

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(hasEvent)

[Pathway:R-HSA-5654726] Negative regulation of FGFR1 signaling

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