Reactome | Activated FGFR4 binds PLCG1

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Activated FGFR4 binds PLCG1 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654153] Rothfels, Karen, 2014-12-03
dbId	5654163
deleted	[Deleted:5655557] Deletion of instance: 190896
diseaseReaction	[Reaction:R-HSA-5655313] Activated FGFR4 mutants bind PLCG1 - Homo sapiens
displayName	Activated FGFR4 binds PLCG1
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654228] Phospholipase C-mediated cascade; FGFR4 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654151] Activated FGFR4 phosphorylates PLCG1 - Homo sapiens
input	[DefinedSet:R-HSA-5654158] Activated FGFR4 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191028] Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells [LiteratureReference:190978] Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR4 binds PLCG1
orthologousEvent	[Reaction:R-CEL-5654163] Activated FGFR4 binds PLCG1 - Caenorhabditis elegans [Reaction:R-DME-5654163] Activated FGFR4 binds PLCG1 - Drosophila melanogaster [Reaction:R-GGA-5654163] Activated FGFR4 binds PLCG1 - Gallus gallus [Reaction:R-XTR-5654163] Activated FGFR4 binds PLCG1 - Xenopus tropicalis [Reaction:R-DRE-5654163] Activated FGFR4 binds PLCG1 - Danio rerio [Reaction:R-SSC-5654163] Activated FGFR4 binds PLCG1 - Sus scrofa [Reaction:R-BTA-5654163] Activated FGFR4 binds PLCG1 - Bos taurus [Reaction:R-CFA-5654163] Activated FGFR4 binds PLCG1 - Canis familiaris [Reaction:R-RNO-5654163] Activated FGFR4 binds PLCG1 - Rattus norvegicus [Reaction:R-MMU-5654163] Activated FGFR4 binds PLCG1 - Mus musculus
output	[Complex:R-HSA-5654166] activated FGFR4:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-190326] Autocatalytic phosphorylation of FGFR4 - Homo sapiens [Reaction:R-HSA-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654163
summation	[Summation:191500] Recruitment of PLC-gamma by FGF receptors has been best stud...

Referrals

(replacementInstances)	[Deleted:5655557] Deletion of instance: 190896
(normalReaction)	[Reaction:R-HSA-5655313] Activated FGFR4 mutants bind PLCG1
(hasEvent)	[Pathway:R-HSA-5654228] Phospholipase C-mediated cascade; FGFR4
(precedingEvent)	[Reaction:R-HSA-5654151] Activated FGFR4 phosphorylates PLCG1