Reactome | POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)

Schema > Reaction > Entries

POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity	[CatalystActivity:5649731] DNA-(apurinic or apyrimidinic site) endonuclease activity of NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649732] Orlic-Milacic, Marija, 2014-11-21
dbId	5649725
displayName	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA - Homo sapiens
input	[Complex:R-HSA-5649715] NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells [LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
orthologousEvent	[Reaction:R-GGA-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Gallus gallus [Reaction:R-XTR-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Xenopus tropicalis [Reaction:R-DRE-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Danio rerio [Reaction:R-SSC-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Sus scrofa [Reaction:R-BTA-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Bos taurus [Reaction:R-CFA-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Canis familiaris [Reaction:R-RNO-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Rattus norvegicus [Reaction:R-MMU-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Mus musculus
output	[Complex:R-HSA-5649730] NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-30977] SUGP [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5649708] NEIL1,NEIL2 recruits POLB to incised AP site - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5649725
summation	[Summation:5649814] POLB (DNA polymerase beta) acts as a 5'-exonuclease to remov...

Referrals

(hasEvent)	[Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
(precedingEvent)	[Reaction:R-HSA-5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA